My bow is set at 55# but I would like to go to 60#. I use a wisker biscuit, super nock and cobra sights. It is sighted in for 20, 30, 40 & 50 yards. If I do tighten it down to 60# sill change my alignments?

Yes you will have to retune the bow and make sure your arrows are spined correctly for the added draw weight.

You will also probably have to readjust your sights

Thanks for the reply..........guess I'll leave it as it is