I have a browning .300 mag with the boss and I am going to load some 110 grain XFB barnes bullets to go after coyotes. What troubles have you had with this. What sweet spot should I start out with on the boss?

I believe you would have better accuracy with a heavier bullet due to the low BC of a 110gr bullet . You obviously aren't worrying about the hides so I would use a better bullet than a 110 gr . I know its faster to start but it loses speed fast to .

barrel twist is going to be a problem, I tried the Nosler BT's in 125 caliber and at best they got puked out the barrel. I have the Browning M1000 Eclipse, same a-bolt action with Boss with heavy barrel and bedding block, the 1 in 10 twist doesn't seem to stabilize the bullet. My buddy's Savage 110 had the same problem. 150 grainers are much better stabilized in the barrel <over the 125> but i use a 165 for all my long shooting duties now, slightly longer ogive and the weight gives it a higher bc.It just plain works in my Browning. I will check my book on the Boss, but if i remember correctly, 150 or 140 grain was the lowest shown for the 300 with a "sweet spot".

Although I've never tried something as light as 110 grains, I've never had any luck developing an accurate "light" load below 180 grains in my Model 70. The BOSS just added to my frustration. Unless you have tons of time, money, bullets, powder, and patience, just blast them with an accurate 180 grain slug.