I don't know the trajectory of a 22 L.R..
So what yardage would you sight in a scoped 22 L.R for?
I'll be using it for Squirrels in open woods so shots could be from 5 yards to 75 + yards if I wonted to.

I've never sighted in a scope for a 22 before I've allways used open sights..

I sight my 22LR squirrel guns at 50yards. Most 22LR becomes erratic after that. Also, I never shoot a squirrel past 35 or so yards.