@ 100 yards I'd grab the 30-06. heavy knockdown and good accuracy at moderate distances

.50 cal muzzy got my vote. I love the smoke and they wack deer as good as any centerfire.

muzzle loader
other choices not legal where I hunt

I voted 06 because my fav caliber, 35 rem, was not listed.

I voted 30-06 but would have voted .270 if it had been there.

I voted .50 cal, too... I haven't even taken my 7mm out of the case since getting mine. I've dropped deer at 100yds with iron sights, so, I feel comfortable shooting out to 150 yds with mine; but, I do use 150gr of pellets and power-belt bullets. I figure, if the velocity isn't enough to kill one, the weight of the 285gr. bullet will at least knock it senseless for enough time for me to get up there and beat it silly with a stick.

i shoot a 300 mag

I own a 30-06 and wouldn't trade it for any other caliber. I've killed bull elk, a B&C black bear, and many whitetail with it and it's always got the job done.