well if you want to use an 06 but don't want to use the accelorators, try the 125s. you get great accuracy, power, and range with them. i haven't tried the accelorators but i do have some. outside of this forum though i've almost always heard that they worked well but hey. i'll have to try them out.

another vote for the 22-250, you can shoot yotes, hogs (head shot) and ANY varmint effectively. also, it will cut through 30 mph winds very well.
i have a Rem 788 in the 22-250 and it shoots great. it's soo much fun to shoot jackrabbits past 150 yards with it.

also, it doubles as a good deer rifle for me for NECK shots....yes, i have killed them shooting them just behind the shoulder, but there was not a drop of blood both times (one at 40 yards, the other 140 yards) so i won't be doing that again. i shoot nothing but the rem 55 grn psp round, it's has all around use for me and it's fairly cheap too.

Im gonna have to go with the Remington 7mm Ultra Mag.