I have been wanting to get my hands on some speer 180gr grand slams but everywhere I check they seem to be out of stock.
how about some opions on some other 180gr bullets .......using primarily in 30-06 and possibly 300RUM

I currently have 150gr Hornady Interbonds, 165gr Hornady SST's & recently bought a box of 165gr Sierra game kings

For deer only,the 165gr to 180gr ballistic tips work great.The accubond in the same weights is a good choice for deer,elk or moose.For the largest big game.the 165gr to 180gr tsx is a great bullet.

I would/will be using the 180gr for moose /black bear

Personally, I wouldn't be shooting anything lighter than 180 grain out of the 300. The Speer hotcore is a great bullet. I used them in the 300 for a lot of years. I found that the ballistic tip was too fragile. The 30 06 will do great with a 165 grain. The Hornady's are a great bullet too. I haven't lost anything that I shot with them. Weatherby factory loads them in their cartridges, and they perform excellent. I am loading the Hornady 140 grain boattail in the 270 Weatherby magnum, and they are leaving the muzzle at 3400 fps.They are extremely accurate, and a deer hit by them never moves more than 20 feet from point of impact. The 130 grain Hornady gives complete penetration on elk,and they rarely take a step. I recovered one190 grain boattail that was launched from the 300, and it was mushroomed perfectly, and weighed 152 grains. That was after passing through a shoulder and chest cavity and lodging under the skin on the off side. You can't go wrong with a Hornady, and everybody carries them. I have the grand slams and partitions, and I haven't seen any difference in the way that they perform on game. Dead is dead.

I have tried the 180gr speers and they shot terrible out a 300RUM and a 300winmag. I am talking 2.5MOA but they shot fast. I mean I was getting 3350fps with 94gr of H1000. No pressure signs.

I now shoot 180gr Accubonds for moose. And plan on using that for elk next year. I also like partitions and TSX. For deer, I still use bullistic tips.

I would try the Sierra GameKings. I have not seen any difference between the performance of the Sierra versus all the expensive bullets. I shoot the 200 grain Sierra bullets, and I am very happy with the performance(accuracy and killing ability). We have been loading 165, 180, and 200 grain Sierra bullets for over 30 years-they have not let us down yet. I have also been shooting some 165 grain Ballistic Tips, they shoot well. I just did not see any difference between the BT and the GK, so I went back to the GK. Tom.

The Speer 180 Grand Slams are great all around big game bullets - maybe not really necessary for deer, but they will work for everything from antelope to moose.

The same could be said for the 180 Hornady Interlock and the 180 Accubond.

I am a Nosler fan so I would go with the 180 Accubond

Stick with the known brand name good bullets like Nosler, Hornady, Speer, Core Lokts etc, which ever one youfind shoots the best out of your gun. Deer 150gr to 165 gr. elk 180gr.

In no particular order:
180 Nosler Partition or Accubond
180 Hornady Interlock or Interbond
165 - 180 Barnes TSX
180 Swift A Frame

Could also try looking on ebay my partner picked up a stack of GS's on there last month and after shipping, etc they were still cheaper then locally.