I have successfully taken deer with.243, 6.5 X 55, 7 x 57, 300 Savage, 30/06, and .50 round ball..........all worked great.

30-30 and 30-06. 30-30 is my favorite though. I don't have many shots over 100 or so yards.

A lot of great ones to choose from, for deer only the 270 win or 2506 would still have to be high on my list but that being said I have moved to a 7 rem mag and haven't thought twice about it

I say the one that gives you the most confidence is probably the best choice.

300wm,300wsm as a back up.

Short range - hunting the bottoms 35REM or Marlin375 (I love my leverguns)
Long range - .270 or 7MM Mag
Super Short range - High Country

30-06,works good for me

The last few years I've been a 280 guy. However, I have had other favorites over the years.

I use a 30-06 and hunt in the mountain- longest possible shot being around 130 yards.

I love my .270 and my average distance here in Mississippi is between 50 to 60 yards, but have made shots up to 225.

I hunt Oklahoma and Kansas all big pasture hunting. I use my 30-06 and my sticks. Most shots 100 yards and greater.