within 150yd running broadside in a field ill take the shot everytime. I've shot at 2 running deer and both were put in the freezer with 1 shot and both dropped on the spot. it's all about you're abilities and what you're comfortable with. Around here we do alot of deer drives so thats the only shot you get alot of the time. I've let more go than I have shot running though for the simple fact that I didnt like the shot. To each his own.