I have a Ruger Model 77 MK11, stainless/synthetic with a 22" barrel in 270WSM. I would like to shoot 150gr Hornady bullets in it.

Does anyone have one of these, and if so, what powder/primer combination has worked best for you accuracy-wise ???

I bought my 270WSM when they first came out and reloading data was hard to find. We had to interprolate between what loads we could find.

My gun is a Winchester Model 70 with a 24" barrel. But I've also loaded for a friends Browning Hunter with a 23" barrel.

I tried 130, 140, and 150 grain bullets. I tried Hornady SST in 130g. Nosler BST in 130 & 140, Nosler Partitions in 140g & 150g.
Kodiak Bonded in 150g and Barnes 140g TSX.

I stuck with the Barnes 140g TSX. In my gun they were as fast as the most of the 130g bullets with the added punch of a 140g.

The 150g dropped in velocity quite a bit over the 140g. When playing with the balistic software I found the 140g had more down range energy than the 150g because they started so much faster.

But you didn't ask about 140.
So here what I found when I played with 150g bullets
These ARE ALL MAX LOADS. Work up to them.

Federal Factory 150g Partition 3184fps
Hornady SP H4350 56.5g WLRM 2978 fps -From Hornady Website
Hornady SP H4831SC 60g WLRM 2962fps - From Hornady Website
Nosler Partition H4831SC 60g WLRM 2942fps
Nosler Partition MagPro 70g WLRM 3100 fps
Kodiak Bonded MagPro 70g WLRM 3100
Speer SP Retumbo 70g WLRM 3136 - From Speer Website
Winchester Factory 150g Powerpoint 3057 fps

If I had to choose a 150g load it would be either 70grains of MagPro or 70 Grains of Retumbo.

Thank you or the info --- In the accuracy department, what was your best group size you got ??? At present, with factory Winchester 150gr ammo I will usually get a 3 shot group of 1/2" --- two holes touching, and 1 flyer 1/2" high left. The only reason I want to handload is that I cannot afford to be continually buying ammo for $27 a box. I have reloaded all my life, and enjoy the savings very much.

I have the same gun, using the 140 gr Accubonds and 58.5 gr or IMR 4350 I average 1", with the 140 gr SST's and 58.5 gr of H4831sc group size is down to about 3/4". Haven't tried the 150's except for the WW factory load. I figured the 140 gr Accubond can be one load for everything. I do have some 130 gr SST's and BT's and some 140 gr Sierra's that I haven't had a chance to load for yet. So many rifles, so many cartridges I just can't get to them all.