Great work guys. A lot of opinions. And it seems to me that a lot of you (including me) rate their charges depending on bullet selection.
But besides the powder charge debate, I am also seeing a lot of differences when bullet choice is thrown in. And logical too. But I sort of disagree with Builder's statement about a 300 gr sabot kills more effectively than a 250. I know what he meant but the wording may have been a bit off. Let's face it, Semisane said it best "Dead is dead, right". I believe what Builder was meaning to say that if both bullets were traveling at the same velocity than yes, the 300 gr would have more kenetic energy delivering more hydraulic shock to the animal hence causing more tissue damage (more effective). However the 250 with an equal charge will be traveling faster than a 300. How much faster I do not know without a chronograph. Now, does this increase in velocity nullify the extra 50 gr of bullet weight? How much faster must a 250 gr bullet go to equal the kenetic energy of a 300 gr bullet.
But then again, there is another factor that comes into play and that is penetration. On a whitetail I don't think it makes a hill of beans difference. The faster 250 will blow thru a whitetail's lungs the same as a slower 300 gr. But if I were to be hunting anything larger than whitetails, I would prefer the slower 300 gr which would in all likelyhood provide greater penetration.
Wow, this bullet debate is going to open up a whole new can of worms.
Am I a trouble maker or what!!! :)

My groups on my Knight Disc open up when I go over 80-90grs of Goex FFF...My current load is a Hornady .430 XTP in 300gr...It groups well with 80grs and I've killed several deer with it...The ones I didn't want to run off, I hit high in the shoulder or low in the neck and they fell right there...None of the lung shot deer went over 50 yards...I'm happy...

In my .54 caliber flintlock that I built in the 80s, I started with 120grs of Goex FF...After a few years I backed down to 100grs of FF and for the past 10 years or so I've been using 80grs of Goex FFF...

Dang if I can tell a difference in how well that round ball kills...

I shoot whats most accurate in my gun with such and such bullet.

100gr blackhorn209 in my Optima's - Wolf with the 250gr Thor
100- 110gr " both charges are very close in accuracy" blackhorn209 in my scoped optima with the 250gr powerbelt aerolite.

You can't and never will. Wind drift alone is off the charts compared to a 270 or 308 CF rifle.

Don't forget some states are not allowed to hunt with a CF rifle. I can see why those people are trying to get the most out of a shotgun or ML.

I try to get the most out of mine too but that doesn't mean I have to use the mostest powder.;);)

Bronko yes, mine was the shorter version and yes the 300 gr will do a better job of killing lol.Bronko look at the data on the PT gold .260 and .300 or the .250 and .290 TEZ with 110 gr Bh 209. they leave the barrel at almost the same velocity.and i feel even on smaller deer size animals at closer ranges the .300 is still more effective and we know it most certainly is at longer ranges.both most certainly will kill, any way we slice it.so will big slow heavy lead with nice metplates. i won't use a hollow point pure lead conical myself, since they tend to come apart at closer ranges. great thread you started here with a lot of good info.:party0005: Ray

Could be, it need go the square root of 300/250 times faster.

Well from my records I normally start at 80 grains when checking for an accuracy load so I have the 300 gr GD figures for that for 100 yds 1705 Foot Pounds
For the 250 with my triumph deer load of 110 grains I have figured 1560 Foot Pounds for 100 yds.
Now since a 250 GD will drop a deer on the spot with 850 FP at long range which I know because I have done it. The only advantage I can see would be if the deer were standing one behind the other and you were trying for more than one, which I would not do any way and since I do use the 300 for bigger game like elk the only real difference I see here is in the trajectory.
Guess how much that is.