I have never had the chance to hunt a pronghorn. I may in 2007. I hear a 2506 is a good choice. What do you guys think? What would you recommend? Thanks in advance.

The 25-06 is a very good choice as is the 270, 280 and 7mm-08. Just to name a few. Any flat shooting rifle from 25 caliber on up would be my choice. I have taken a few with the 6MM Rem as well.

270 is a fine antelope cartridge.

You would be hard pressed to find a better lope round than the 25-06.It fit's nicley in between the .243 and the .270 for goat shooters.
BBJ

anything from .25-06 to .280 would be a great cartridge. I think the specific gun model matters more for antelope than the cartridge choice. Course it depends on how far you're wanting to reach.

My personal choice would be the 7mm WSM. With the right load you can get it dropping less than 12" at 400 yards with 2k ft/lbs!

Pretty impressive.

25-06 is a very good round. My brother-in-law hunts elk with is as well.
I would recommend two things however.
1) Use a bullet with rapid expansion. I'll never forget the goat I shot with my 7mm RM using 150gr core lokt's. Shot it three times and he kept walking. Finally dropped. I thought I had missed or my barrel was bent. When I gutted him out, you could cover all three shots with a tea cup! No damage, all went right through!

2) Practice long range shooting. 200 to 400 yards. Know your balistics (drop and windage for whatever round you choose). I see you're in IL and probably don't need to shoot at those distances. Goats can be under a hundred, or out to 400. And I can just about guarantee it will be windy.My longest shot was 385 yards. Dropped like a wet card table.

I love antelope! Right next to my mashed potatoes.

Yeah, It seems to work for everything

Brutal..no 308? and by the way, who's that pic on your avatar, she's pretty hot

I have taken a couple with my 7mm rem mag and it performed admirably but having said that if I was buying a rifle for antelope it would be a .25-06.

I asked him that, he said it's "My dream girl, who will remain nameless."

When I first saw it, I thought it was a picture from CNN and it was a policewoman from India or something. I think a .308 would be impractical, more gun than neccessary. A smaller bullet would be better.
I would say a .25-06 or a 7mm-08. If all you're going to do is deer and lope hunt, than a 25-06.It can also be used as a varmit rifle. If you want to hunt elk later, use a 7mm-08.
I think a 7mmWSM would be way too expensive. Since it's still a wildcat cartridge and isn't produced that much. 25-06