RE: Pronghorn Rifle
anything from .25-06 to .280 would be a great cartridge. I think the specific gun model matters more for antelope than the cartridge choice. Course it depends on how far you're wanting to reach.
My personal choice would be the 7mm WSM. With the right load you can get it dropping less than 12" at 400 yards with 2k ft/lbs!
Pretty impressive.