I have a Ruger Redhawk in 41 Mag. Put some good wrap-around grips on it like Hogue or Pachmars and it disappates recoil pretty well. I shoot 210 Rem. semi-wadcutters in mine for practice and recoil is minimal. With all that said, I'm 6'5" and 280, but I think with handguns that doesn't make that much of a difference. 41 has more than enough power with the CorBon 250s or similar rounds to put down a whitetail up to 50 yards. You will notice more recoil from the hunting loads, obviously.