RE: Who can shoot this gun with this recoil?
IMHO the 378 Wtby is worse than the 460 by far. And with a good brake the 460 isn't bad. My wife (125 pounds) and I have shot the 460 a few times and its a handful, but its very manageable. And we've both shot the 50 bmg with a brake a lot.
As mentioned its all subjective to the shooter. I know folks the say my little 44 special is horrible and they amost dropped it with mundane 200 grain lead loads. On the other hand I have a 44 mag 329 smith thats scandium and super light. I've had folks tell me it kicks horribly and others tell me its very easy to shoot. Even with 300 grain bear loads.
The only way you'll know is to just go shoot.
Jeff