Well from my experience the regular lead ammo always seems to jam every other shot. I'd go with some sort of hollow point would be the best ammo. I have gotten a yote but it was with a .300 Savage so i'm just throwing some ideas in the air for you. As for shot emplacement, some would tell you aim for the head but i think if that is you are close enough and are able to take the shot but i really wouldn't recommend it. Just behind the shoulder is good (2 - 2 1/2 inches behind it and 2- 2 1/2 inches above the underside line). As for shoot head on as if they were facing you, that is little tricky but aim mid chest. The neck area isn't really good because you are most likely just going to wound it and leave it to die a slow death if it doesn't end up surviving. I hope i gave you some ideas but give this some time and i'm sure more will come in and give you much better advice then me.