kind like everyone has said in the other replys, which are you most comfortable with? which is more natural? my left eye is doma=inate, but i mainly shoot a bow right handed, but i also shoot a gun left handed. i picked up a left handed bow a while back and decided to test it out ,, i can shoot almost as good left handed ,as i do right handed, but right handed is more natural, which is something you want while hunting, seeing that you are already under the pressureof makeing a good shoot. i would pretty much think the same thing with comp shooting. just my 2 cents thrown in.