I get good accuracy and terminal performance with 80 grains of 777 under a 260 grain .451 Nosler Partition HG in high pressure sabot.

Took a broadside doe last Sat. evening at last light, a 100-120 yard off hand shot. The bullet clipped the near side leg bone, just barely grazed the heart, and missed the far side leg upon exiting through a rib. She ran about a hundred yards into a picked cornfield on 3 legs and no lungs. Entry wound was about 2-3 inches across, exit wound about the size of a quarter. I've yet to recover a Nosler from any of the deer I've dropped. Based on from what I've seen, the Nosler is devastating. The only downside to them is they are a little pricey.