The most preferrable method is to jump out of the tree and slit their throat. Aside from that, the first consideration is to select a caliber and bullet that have the best possible results. After 40+ years, I've settled on 7mag and ballistic tips. The caliber is good to all ranges short of 500 yards (if you've practiced the shots!) with plenty of energy and speed. The ballistic tips from Federal Premium have proven to me and those in my camp that they are well worth consideration. Since going to the ballistic tips the farthest any deer has gone after hit is 30 yards. Most have folded up like a cheap lawn chair. As for bullet placement, the boiler room is by far the best bet. I imagine the heart in the site picture and go for it. However sometimes the lung/heart area is as good as it gets. Anything just at the shoulder point in the middle will get the desired results. See post by seal-hunter for optimum placement. The best advice is practice, practice and then practice. A well placed shot, regardless of whether your shooting a bean flip or a RPG is at the center of the issue. Those neck or head shots, although great for the bragging rights (and I've been forced to make a few of those) are generally low percentage shots not best fitted for a sure clean kill. Just concentrate, aim at a particular hair on the boiler room and relax for the squeeze. Best regrards, Jim