Hk45usp go with the 22 Hornet ,because of the ammo . The 218 and 219 are both faster but not by that much . It costs about 40 bucks a box for the 218 and the hornet is about half that . I have a 218Bee in a 1894 Marlin and the 22 Hornet in a Mauser bolt action . They are both centerfire rounds and they say they are legal for deer in Oregon ,but I wouldn't use them .