Im my opinion, it is not the caliber, but the shooter. Alot of guys have said the 30-30 is the most responsible, that may be true, but as I see it a .375 H&H wouldn't kill a deer if you shot it in the foot. A good shooter can make due with what he/she uses. It's been said the greatest rifle/caliber in the world just so happens to be the one that your carrying at the time.