I'd think it depends on the reason for the lost game.
If it's poor shot placement, it's probably someone shooting a magnum caliber they can't handle.
Other than that, I'd say the .223's and the other .22's that just are not suitable for big game! Most of the "misses" with the .22's are probably really "hits" that don't provide a blood trail, and end up being unrecovered dead deer!