I don't like seeing any caliber smaller than a .243 used for any big game. Yes we can debate if deer and antelope are or are not big game. But for this thread we will consider them big game. Anyway I know some people like to use 22 calibers (.223, 22-250 and the new 223 WSSM) for hunting deer where it is legal. But I think they are playing with fire and will be looking for wounded animals. Yes they might kill them on a regular basis but sooner or later they will flub a shot just enough to wound a deer. Its just my honest opinion but there are reasons that some states have a caliber limit! I'am sure I will take heat for this, but the 22 calibers are made for varmits and only varmits! I agree the .280 is great for any game in the lower 48, stick with it and get to know the gun well and it won't dissapoint you.