It is very difficult for me to shoot a high letoff. It can be done, but in my case, it was much more difficult. I shoot fingers and my choice of bows is the Hoyt Protec with the cam 1/2. I had the opportunity to try both the 65 and 75% letoff. I prefer the 65% because there is more pressure on the string when I draw and much, much easier to get off the string when released. A few things to look for are longer axle to axle, longer brace height and longer sight window to accommodate your new anchor point. Also, you will need a good magnetic rest and cushion plunger. A launcher type rest will not cut it for fingers. I shoot an Oakie magnetic rest and Cavalier "the tone" button. Both are fully adjustable to fit any finger style of shooting and fine tune the setup to the precision you can't beat.
If you have any questions, post your thoughts on this segment and I will get back to you.
Good Hunting...