Exact and repeatable hand placement on the bow is so critical to consistent accuracy.
I want something I can grab with my goretex gloves on when it's 20 below and not think twice about my grip.
Deflex riser + 65% or less letoff + smooth hard plastic or wood, HIGH WRIST grip.
With such a setup, your hand naturally and automatically slides into exactly the same position each and every time you grap the bow, especially if you use talcum powder on your bowhand or use a slick glove. It's almost impossible to torque that kind of rig. Of course, you get a higher brace height so the chrony numbers aren't nearly as impressive, but I prefer having the shooting qualities instead of the excess speed.
The Hoyt ProVantage/SuperSlam risers are still my all time favorites because they're SO easy to shoot well.