What are you hunting? If you don't leave New England you won't be doing much BIG game hunting, maybe 90% deer with an occassional moose hunt if you're lucky enough to be drawn. I'd go with the 30/06 or even a .308, just for ease of getting ammo.

BUT if you hunt areas where really long shots are expected, then maybe a magnum makes sense. A 30/06 is fine out to 250 and a bit beyond, on deer.