I love my .270 and use it often on deer sized game. But if I were going to start a new battery from scratch hunting everythng from prarie dogs to moose, it would probably be something like this.

1. Varmints (up to yotes) .204 Ruger or 22-250
2. deer/black bear: either a 7-08 or .280
3. Elk/Moose/big bear: 338 WM