When it turns cold, I take an advil in the morning and one in the afternoon. I find that they take the sting away and the stiffness that you feel when you get cold. I don't know if they thin your blood or just mask the pain, but I find they make being in the cold for extended periods no problem at all, as long as you wear warm clothes and boots of course. I'm always the last in my group to get down when it's cold, been doing it for years.