My work buddy had a Remington in the grand old 375 and I had a Sako in 338; we both had 300 grain loads that day, shooting from the stand. I really could not tell a difference; I assumed the 375 would hit harder on the shoulder but it wasn't bad. Note that we were not bench shooting, though. The 300 grains were the only time I understimated my eye relief. (Biscuit has a thick head, tho)