I really don't think that a big 350 or 400 grain slug fired from a 50 caliber ML would come close to reching the velocity required to make it blow up. Your talking about 1500 to 1800 fps at the very max from a bullet like that and probably 90% being closer to 1600 fps.

When you put 150 grains of BP or 777 or what ever in the gun you mostly get a bigger kick because of the added weight of the powder, and a lot of flash and smoke from the powder burning outside the barrel. About half+- of BP is burned out side the barrel and that percentage increases as you increase the ammount of powder you use in the gun.

Most of the complaints I here are that the bullet didn't expand much if at all. They gripe about a bullet passing all the way through an animals lungs, exiting and killing it. I can't figure it out. A dead animal and a 1/2 inch hole all the way through its lungs???? Things that make you go hmmmmm.