The one differance that I have read about between the hornday and nosler is that the nosler is designed to shed more weight ,to keep the frontal area of the mushroom to a certin size for deeper penertration. If you would shoot both into a test medium the hornday would end up with a larger diamiter and the nosler would penatrate a little farther. I would shoot what groups better or you "think" is better. In my gun it is a toseup for accurey but I have 2 boxs of the nosler left.