The reviews I read on all of them (LAR Grizzly) a few years back showed them to be well made, accurate, and reliable. I'd think the .454 or perhaps even a handloaded .480 with heavy, hard cast bullets at semi-fast/moderate velocity would provide great penetration (allegedly will fully penetrate a Cape buffalo length-wise!)without the wrist-snapping recoil of a custom Linebaugh, but good luck whichever way you choose! (Did you see the review on a Bowen titanium barrel/cylindered 5 shot Ruger Blackhawk .50 AE several months back that weighed only 21 ounces? Ouch!! :-)