I am assuming you are shooting a .50. If so, the 295-grainer is on the light side for elk. I'd use a 444 grain Powerbelt for elk and anything as large or larger! The 295-grain is OK for deer and smaller. What I said goes even more if you are shooting a .54, since the sectional densities would be even lower if the bullet was bigger around at the same weight! You COULD use the 444 grainer for deer, but it would be unecessarily HEAVY for ordinary whitetails. You could certainly use 100 grains of 777 FFg with any weight of Powerbelt, so even changing bullets would not require you to change you powder measure setting. However, the points of impact of the different bullet weights might require a sight adjustment. Have to shoot 'em to find out!