I prefer feathers from an accuracy, stability and tuning standpoint. However I do use vanes sometimes in particular setups trying to make a certain arrow weight, spine, or FOC. But I don't like them
I find the most common used vanes(Duravanes, AAE) are not very durable at all. One little tear or rip (and they rip pretty easy), and it's time to re-fletch. A feather with even a pretty sizeable chunk out of it will still shoot well (at least field points and mechs). If you are going to go with vanes I would recommend FLex-Fletch or Mullen Marco vanes for best durability..and Bohning vanes are fairly durable as well.
With proper waterproofing Feathers work well in most weather conditions.
Another con to feathers is time needed to fletch them. But I have a Jo-Jan multi fletcher for that and it will do a feather on 6 different shafts at a time, so I can have a 1/2 doz arrows done in an hour. No biggie.