Start with 90 grains loose 777 powder and 295's or 348's and shoot a 3 shot group from a bench. Then repeat with 95, 100, 105, 110 grains. Probably one of those combinations will be fairly accurate, but each gun is different and you have to find your gun's sweet spot. Any of those loads will do the job for deer and elk. My gun like 90 grains of 777 with 348 gr powerbelts and I will be using that for elk next fall.