I use a .30-06 right now for everything, as well as my .50 ML. I have a .223 for varmints. I will get a .260 Remington this fall though for deer and antelpe, and such and then use the .30-06 for elk and black bear and such. I have a fistula in my right arm from dialysis, so my shoulder can't take mcuh recoil. I am left handed but right eye dominant.