Not sure about the 22, but I have both barrels for my 27. The 40 and the .357. I have shot both without any problems for a while. I highly suggest not going with the sig round if you like to reload. Its a pain in the butt to get it crimped enough. From the data, I like the 40cal alot better anyway. Also 357sig rounds are getting harder and harder to find. I bought 1000 pieces of used brass because I figure it will go away one day.