I used the Rem Core-Loct 150 on deer. Shot well from the gun, and killed deer dead. Just a note that the Core-Loct 165 and 180 grainers also shot well from that gun. I handload now, so don't buy any factory ammo, but still have a box or 2 of each left. I wouldn't hesatate to use any of those weights on deer, but I think that the 150's upset inside the deer better and thus transfer more energy to the deer. I'm sure there probably isn't really that much difference and if you put one of them thru the vitals, any will work.