I'm right eye dominant and shoot left handed. If you shoot with both eyes open and the bow canted a little and stare a hole in your target, the cross dominant issue is moot. But if you use a sight system of some sort--gap style using the point as a sight pin or look down the arrow--the cross dominant situation will give you fits unless you close your dominant eye. This, to me, is the very thing I left compound shooting to get away from--sight shooting, closing eyes, etc.