i usually club em with my 7mm rem mag she seems to lay em down lol. Just a little too much damage to the body. I really need to invest in a 22-250 but i'm goin to have to wait till i'm done university. As for the 22 on yotes ya it ain't goin to happen, you need more jam than that to get the job done. a 7mm is definate overkill but its all i own larger than my 22 so i'm stuck with it till i can buy myself something else....