I don't know a whole lot on the .243 but i shoot a 22-250 loaded with the 50g winchester ballistic silvertips. The only time i had alot of pelt damage with this one is when i shot a red fox at about 150 yds. broadside, when it went in it hit the shoulder on the other side of the body it blew a huge hole about the size of a tennis ball out that side. Besides that i have never really had any problems i shot a coyote in the back of the head at 260 yds. (all luck) and the bullet never exited. It seems to me if you can stay away from the shoulder and any of the other larger bones you should be all right, most of the time the bullets fragment on impact so you might have a few little exit holes but nothing to horrible. Hope this helps.

Tom