I know very little, but here is my .02 cents... I own a 243, and i don't think a load is going to make that gun leave much smaller of a exit hole. The 243 will go in and out. I shot a deer this year with it, and it when in and out at 100 yards. I would buy a 22-250 if you are only hunting coyotes and other predators i wouldn't buy a 243 ... i hunt just about everything with mine. Even shot a grouse in the head from 30 yard this year.... good eatin!!!

hope this helps a little, there are much better informed people on this site than me!!!!!