here in ms.you have to take the primer off each time you get within 100' of a public road.my experience has been,once the cap is removed moisture can get between the nipple and charge so i just shoot mine when i get ready to go and run a patch down the barrel when i get home,pop a cap to dry the nipple then reload when i get out of my truck or at my stand when i start to hunt the next day.if i did not have to take the primer off,i would leave the gun charged and both safeties on until i shot a deer.as long as the nipple is intact and water doesn't get in the barrel,i don't think you would have a problem.i doubt that many states allow the gun to be left loaded in the auto.