IMO realistically you aren't going to be dialing your power after game is spotted unless the game is at a long distance or head down feeding. You typically set it to what you expect the shooting situation to be beforehand.
Then you have to figure in low light, most of my shots are a half-hour before sunrise or a half-hour after sunset (actually one hour here) or even moonlight for Hogs. There is a low light sweet spot for most people as far as magnification goes, it is an individual thing, it has to do with your pupil diameter.
Most people have a pupil diameter between five and seven, with 7 standard. I misspoke before my fixed scope is 6x42 (not 44). Which gives a scope exit pupil diameter of 7. I use my binoculars mostly and only use the scope or rifle the few seconds before the shot. Side note a pair of binoculars that matches your scope can be helpful especially in low light if one or the other is drastically better than the other it causes me issues.


My 4-12X52 scope gives *me personally* the best light and definition at around 8X-10X. You may also want to experiment a little to find the best eye relief, crowding the scope doesn't make it better. Some things you just have to get used to, technology is only going to take you so far, and then it is on you to adapt. You may seldom to never use the highest magnification, but having the option can be nice when you want to pop a Yote on the horizon near the end of your hunt. Last note, changing the magnification can slightly change where your bullet strikes, I usually zero at max magnification and am good enough to sho0t small groups, my zero does change slightly as I change the magnification, I've heard this can change from scope to scope and as my scopes are high end I imagine it can get worse with lesser scopes.