Poachers are slick, they will eventually figure out where the game is and places with little human traffic. The only way we kept our sanctuaries safe was through regular patrols. usually way late-early morning. Word gets around after a couple of poachers get busted.
The local State lands guys put up signs warning of Rabies in an effort to reduce foot traffic in quiet areas. I've thought maybe some signs 'Danger Lymes disease' might work just as well.
All the game needs is quiet areas with little foot traffic and/or hunting pressure.