Ive used mostly magnum revolvers for hunting big game
in my opinion the one tip to success is get into under 70 yards before you fire and spend a great deal of time at your local range practicing at 60 and 100 yard targets,
shooting from field positions not shooting off a bench rest.
shot placement with any handgun cartridge is critical to getting consistently decent results
and if your using iron open sights ranges should be limited at under 100 yards in my opinion
hard cast bullets of proper design and weight work reasonably well,
remember critical, precise shot placement and a good knowledge of the anatomy of the game helps immensely
and heavy for caliber, hard cast projectiles provide deep penetration,
Id suggest you think of handgun hunting as similar to archery your lethality is dependent on precise shot placement
suggested bullet weights
357 mag= 158 grain-180 grain
41 mag= 220 grain-250 grain
44 mag= 270 grain-320 grain
45 caliber -300 grain-350 grain
480 caliber 350 grain-400 grain
50 caliber 400 grain-480 grain
Ive used a longer barrel 44 mag revolver , loaded with a 310 grain lee gas check bullet on most hunts over 21 grains of h110 powder
its zipped through most deer and hogs and Ive taken two elk in 50 years with it. (both at under 70 yards)in both cases the bullets exited the far side chest
in both cases a lower chest hit was selected,
from what Ive seen, the 500 mag is significantly heavier, noticeably more powerful, and it hits considerably harder, its also far heavier,
I reload for several guys that own them,
the 500 S&W revolvers are harder to control and less easy to use, and since a 44 mag is fully up to killing an elk and leaves an exit on a chest hit elk I doubt its more lethal.
I hand load and cast bullets for 3 guys that own and hunt with 500 S&W mag revolvers
22 grains of blue dot powder under a 440 grain hard cast bullet works ok.
https://leeprecision.com/mold-dc-c501-440-rf.html
those revolvers are excellent as far as accuracy and have all the power you need,
but in my opinion loading them with anything other than a 350 grain too 500 grain hard cast ,GAS CHECK,bullet,
and pushing them past about 1400 fps-1500 fps makes them recoil too hard,
and adds little too nothing to their potential lethality,
as even at that level they zip though hogs and deer at 100 yards and with iron sights,
most people are hard pressed to shoot well enough past that distance.
Ive also used and own a 10" dan wesson 445 super mag, it shoots the same 44 projectiles as the 44 mag but at about 1550 fps vs about 1350 fps in the 44 mag
https://leeprecision.com/mold-dc-c-430-310-rf.html
the 445 DWSM is noticeably more accurate but like the 500 mag its a noticeably heavy pistol
according to info Ive seen the guy in the video is using a 44 mag with 300 grain hornady hollow point bullets
hard cast easily out penetrate hollow points but provide a bit less shock effect.