This is my list as a dedicated hand loader!

#1- Ruger Mark Series .22 RF semi-auto ( small game, personal defense)
#2- Ruger 77/22 SS, 22 RF
#3- S&W X Frame 460 Good for big game out to 125/150 yards, and 410 equivalent shotshells ( small game, varmints at close range). Can be hand loaded with light bullets @ low velocity for plinking, self defense (human), and small game
#4- A large case capacity rifle cartridge, .358 diameter bullet or larger. With cast bullets can be used for small game up to “small” big game, or with jacketed or mono bullets capable of high velocities and flat trajectories. Summary: I’ll choose my .375 AI!
#5- Any good pump action 12 gauge shotgun, with multiple chokes and barrel not to exceed 26” (small game, waterfowl, defense)

memtb