I'd be one unhappy camper. Most of my guns are customs, tuned to my preferences, or inherited from two or three generations back. That said:
Defense: 9mm Glock or Kimber, depending on my insurance payout
Big game/Varmints (Coyotes): T/C Encore pistol w/ 15" 270 Winchester or 7mm-08 Remington barrel
Small game: Ruger MK IV 22 pistol
Blackpowder: Try to find a CVA Optima pistol, but more likely a T/C Encore w/ rifle length muzzleloader barrel or T/C Pro Hunter FX
Anything additional: Mossberg 835