Defense: I'm picking up a Glock 17. That's my duty pistol, and I can't miss work.
Big game: I'm looking for a plain Jane Remington 700 in .30-06. probably a synthetic ADL version. As a do-all hunt anywhere big game option, that's what I'd pick up.
Small game: I'm finding a Ruger 10/22. It's reliable, plenty accurate for my needs, and I've always enjoyed shooting them.
Varmints: this is covered between my 10/22 and the 06. But if I was a serious varmint hunter I'd probably look for an older Savage in .223 or .22-250
Competition: not needed
blackpowder: I'd get a cheapy CVA wolf and go kill some deer
Anything additional that you need: I'd need a bow or crossbow. But since this is a gun section I'll skip that.
I don't have a shotgun on the list. I'd go pick up either a rem870 or moss500 in a field/deer combo that way I get a smooth bore and rifled barrel.
I think that would cover all of my needs and I could get along just fine with only those 5 or 6 guns
Life would be a little less interesting, but my freezer would still be full.
-Jake