Ive carried a dozen different rifles, and several calibers over the last 50 years,for hunting elk and mule deer and white tail deer,
everything from a ruger single shot 270 win, and browning BLR in caliber 257 roberts to a remington 700 in 458 win mag,
I favored my weatherby fiber-mark synthetic stainless 340 mag. and SAKO 375 H&H more than anything else.
my late hunting partner carried a browning BLR in caliber 358 win,
he spent a good deal of time kidding me and calling most of my rifles (##$$%% CANNONS)
and he never felt any urge too change.
the open secret is that they ALL worked just fine,
having confidence in what you carry, and being proficient in its use,
is far more important than the caliber you select,
I was just as successful with 270 win as the larger calibers,
and you certainly don,t need more power than a 270 win provides
but I always had more confidence in the 33-45 caliber rifles
458 win mag
450 marlin
35 whelen
375 H&H