A plain Jane Remington 700adl in .30-06 goes on every big game hunt that I go on. Often it goes as a back up as I have more interesting rifles that I want to play with most years. It's taken everything from raccoons, foxes and coyotes over a call, to deer and elk. I've carried it for bear but no such luck yet. It will likely be my primary rifle when I eventually draw for antelope in Wyoming.
It's boringly reliable at making things dead.
-Jake